Medicinal plants have been used against various diseases for thousands of years, and 80% of the worldwide population still depends on herbal medicines. The medicinal plants Artemisia nilagirica, Senegalia visco, Hypericum perforatum, Vaccinium microcarpum, and Curcuma longa are a few samples of plants that have been effectively used against skin diseases. This natural source has generously provided us with bioactive molecules, such as artemetin, lupeol, hypericin, hydroquinone, epicatechin, and curcumin, which have been used against acne, atopic dermatitis, skin cancer, and skin pigmentation disorders. This chapter presents a list of medicinal plants traditionally used for curing skin disorders, their bioactive molecules, and their modes of action.